anavar

Oxandrolone a unique oral anabolic steroid hormone that is also known as Anavar. Anavar was first synthesized in 1962 and has been used in the medical treatment of catabolic disorders for over 30 years. Anavar is unique because it has great oral bioavailability (can be taken my mouth) and is resistant to liver metabolism. Anavar also does not get aromatized into estrogen compared to testosterone. The primary use of Anavar is to prevent frailty and the loss of muscle mass due to aging (sarcopenia) and other related catabolic clinical disorders such as HIV -related muscle waiting, severe burn injuries, trauma after surgery and hepatitis.

Anavar has been shown to:

1) Decrease visceral fat and total body fat

2) Increase protein synthesis in skeletal muscle

3) Increase dietary energy and protein intake

4) Increase nitrogen retention

5) Increase muscle function, growth, strength and physical activity level

6) Substitute for the natural loss of androgen and estrogen hormones

How does Oxandrolone (Anavar) work?

Anavar increases muscle mass in three ways

1) Inducing protein synthesis in the body

2) Up regulating the androgen receptor in skeletal muscle.

3) Increasing IGF-1 (insulin-like growth factor)

Anavar given to healthy men, has been shown to increase protein synthesis by as much as 44% and improve effects of resistance training.

What are the indications and usage for Anavar (Oxandrolone)?

Anabolic Androgenic Steroids are indicated in patients chronic wasting conditions (the loss of muscle mass) to prevent frailty. Such conditions include  sarcopenia, AIDS related muscle wasting, severe burn injury, trauma following surgery and other catabolic disorders. Anavar is approved by the FDA for the treatment of patients with prolonged use of corticosteroids to prevent protein catabolism and has been used to promote weight gain after extensive surgery, during chronic infectious states, or after severe trauma.

How is Oxandrolone (Anavar) absorbed?

Anavar is an oral medication that is absorbed across the gastrointestinal tract. Peak serum concentrations of Anavar occur within 1 hour after ingestion. In the body, Anavar is 95% bound to protein, which may contribute to the steroid’s stability and resistance to breakdown by the liver.

How is Oxandrolone (Anavar) metabolized (broken down)?

Unlike other anabolic steroids, Anavar is rather resistant to liver biotransformation. Approximately 28% of Anavar is excreted in the urine unchanged.

What are the side effects of Oxandrolone (Anavar)?

The most common side effect of all AAS is liver toxicity and cholestatic jaundice, among others. Such adverse effects on the liver are demonstrated in patients utilizing high dosages of Oxandrolone for greater than 1 yr and concomitant use with other anabolic agents. No evidence suggests that short term use of Oxandrolone had led to the development of liver function impairment.

Other side effects of Anavar in males include:

Inhibition of testicular function (infertility)

Testicular atrophy

Oligospermia

Impotence (Erectile Dysfunction)

Priapism (Prolonged Erection)

Epididymitis

Bladder Urgency and Frequency (worsening of lower urinary tract symptoms)

Gynecomastia

Acne

Bleeding in patients currently on anticoagulant therapy

Insomnia

Decreased glucose tolerance

Who should not take Oxandrolone (Anavar)?

1) Any male with known history of or suspected prostate cancer or male breast cancer.

2) Hypercalcemia

3) Renal Dysfunction